![]() Don't drive or use machinery for 4-5 hours after taking melatonin. But it can cause some side effects including headache, sleepiness, dizziness, and nausea. Melatonin is possibly safe when taken long-term. When taken by mouth: Melatonin is likely safe for most adults when used short-term. There is interest in using melatonin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. Taking melatonin by mouth doesn't seem to reduce symptoms of depression, and might make symptoms worse in some people. Taking melatonin by mouth at bedtime doesn't reduce withdrawal symptoms in people with insomnia who have stopped taking these drugs. Withdrawal from drugs called benzodiazepines.Taking melatonin by mouth doesn't seem to improve sleeping problems in people who do shift work. Sleep disorder due to rotating or night shifts (shift work disorder).Taking melatonin by mouth doesn't seem to improve pregnancy rates in females undergoing fertility treatments. Inability to become pregnant within a year of trying to conceive (infertility).But it might reduce confusion when the sun goes down in people with these conditions. Taking melatonin by mouth doesn't improve behavior or affect symptoms in people with Alzheimer disease or other forms of memory loss. Diseases, such as Alzheimer disease, that interfere with thinking (dementia).Taking melatonin by mouth doesn't improve appetite, body weight, or body composition in people with wasting syndrome from cancer. Involuntary weight loss in people who are very ill (cachexia or wasting syndrome).Taking melatonin by mouth shortly before resistance exercise or cycling doesn't appear to improve performance. Taking melatonin by mouth can improve low blood platelet counts associated with cancer, cancer treatment, and other disorders. Low levels of platelets in the blood (thrombocytopenia).Taking melatonin by mouth at bedtime for 4 weeks reduces pain in females with jaw pain. ![]() A group of painful conditions that affect the jaw joint and muscle (temporomandibular disorders or TMD).Applying melatonin gel to the skin before sun exposure seems to help prevent sunburn. Taking melatonin by mouth might reduce the amount of sedatives needed for some medical procedures in children. Taking melatonin by mouth or under the tongue somewhat reduces anxiety before surgery in adults. It's not clear if melatonin helps to treat migraines. Taking melatonin by mouth before bed can prevent migraines in adults and children. But it might not help shorten the time it takes for people with jet lag to fall asleep. Taking melatonin by mouth can improve certain symptoms of jet lag such as alertness and reduce daytime sleepiness and tiredness. ![]() It also seems to be more helpful in older adults and those with certain other conditions. It's not clear if it affects the amount of time spent sleeping. Taking melatonin by mouth, short-term, seems to shorten the time it takes to fall asleep in people with insomnia, but only by about 7-12 minutes. Immediate-release products don't seem to work. Taking the controlled-release form of melatonin by mouth before bedtime seems to lower blood pressure in people with high blood pressure. It also reduces pain during menstruation, intercourse, and while going to the bathroom. Taking melatonin by mouth seems to reduce pain and painkiller use in adults with this condition.
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